Li, F;
Ruan, X;
Min, L;
(2017)
Targeting both sides of the GDF15-GFRAL-RET receptor complex: A new approach to achieve body weight homeostasis.
Genes & Diseases
, 4
(4)
pp. 183-184.
10.1016/j.gendis.2017.11.004.
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Abstract
Obesity is a chronic, complex disease, which is associated with several comorbidities, including diabetes mellitus, hypertension, and cardiovascular diseases. It is estimated that the prevalence of obesity among both adults and children nearly tripled between 1975 and 2016, highlighting a huge unmet treatment need. However, the currently available anti-obesity drugs have serious side effects, which limit their long-term use. The finding that the newly-identified brain GDF15-GFRAL-RET receptor signaling complex is involved in stress/disease-induced anorexia will certainly impact our knowledge of body weight homeostasis under healthy and disease conditions. Based on this breakthrough, a new class of GFRAL/RET-based drugs is highly anticipated for the treatment of obesity, as well as cancer-induced cachexia.
| Type: | Article |
|---|---|
| Title: | Targeting both sides of the GDF15-GFRAL-RET receptor complex: A new approach to achieve body weight homeostasis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.gendis.2017.11.004 |
| Publisher version: | https://doi.org/10.1016/j.gendis.2017.11.004 |
| Language: | English |
| Additional information: | Copyright © 2017, Chongqing Medical University. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | Anorexia, Brain, GDF15, GFRAL, MIC-1, Obesity, RET |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Renal Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10123466 |
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