Ma, S;
Zhao, H;
Galan, EA;
Balabani, S;
(2021)
Modulating Flow Topology in Microdroplets to Control Reaction Kinetics.
Advanced Biology
, 5
(2)
, Article 2000309. 10.1002/adbi.202000309.
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Abstract
In traditional reaction flasks, the reaction rate of macromolecular compounds is dictated by the concentrations and distribution of reactants along with their intrinsic reaction kinetics. Controlling reaction kinetics in microfluidic droplets has been proposed through the regulation of flow dynamics, but is yet to be demonstrated experimentally. Here, this hypothesis is verified by accelerating or suppressing macromolecular reactant mixing in microfluidic droplets. The control of reaction kinetics through the modulation of flow topology in microdroplets may enable further developments in modeling macromolecular systems.
| Type: | Article |
|---|---|
| Title: | Modulating Flow Topology in Microdroplets to Control Reaction Kinetics |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/adbi.202000309 |
| Publisher version: | https://doi.org/10.1002/adbi.202000309 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | droplet, flow topology, microfluidics, reaction, shear |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10123438 |
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