Fasseas, MK;
Grover, M;
Drury, F;
Essmann, CL;
Kaulich, E;
Schafer, WR;
Barkoulas, M;
(2021)
Chemosensory Neurons Modulate the Response to Oomycete Recognition in Caenorhabditis elegans.
Cell Reports
, 34
(2)
, Article 108604. 10.1016/j.celrep.2020.108604.
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Abstract
Understanding how animals detect and respond to pathogen threats is central to dissecting mechanisms of host immunity. The oomycetes represent a diverse eukaryotic group infecting various hosts from nematodes to humans. We have previously shown that Caenorhabditis elegans mounts a defense response consisting of the induction of chitinase-like (chil) genes in the epidermis to combat infection by its natural oomycete pathogen Myzocytiopsis humicola. We provide here evidence that C. elegans can sense the oomycete by detecting an innocuous extract derived from animals infected with M. humicola. The oomycete recognition response (ORR) leads to changes in the cuticle and reduction in pathogen attachment, thereby increasing animal survival. We also show that TAX-2/TAX-4 function in chemosensory neurons is required for the induction of chil-27 in the epidermis in response to extract exposure. Our findings highlight that neuron-to-epidermis communication may shape responses to oomycete recognition in animal hosts.
| Type: | Article |
|---|---|
| Title: | Chemosensory Neurons Modulate the Response to Oomycete Recognition in Caenorhabditis elegans |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.celrep.2020.108604 |
| Publisher version: | https://doi.org/10.1016/j.celrep.2020.108604 |
| Language: | English |
| Additional information: | Copyright © 2020 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Caenorhabditis elegans, Myzocytiopsis humicola, chitinase-like genes, cross-tissue signaling, cuticle, hypodermis, innate immunity, oomycete, pals, pathogen recognition |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10119806 |
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