Holyoake, DLP;
Robinson, M;
Grose, D;
McIntosh, D;
Sebag-Montefiore, D;
Radhakrishna, G;
Patel, N;
... Hawkins, MA; + view all
(2016)
Conformity analysis to demonstrate reproducibility of target volumes for Margin-Intense Stereotactic Radiotherapy for borderline-resectable pancreatic cancer.
Radiotherapy and Oncology
, 121
(1)
pp. 86-91.
10.1016/j.radonc.2016.08.001.
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Abstract
Background and purpose: Margin-directed neoadjuvant radiotherapy for borderline-resectable pancreatic cancer (BRPC) aims to facilitate clear surgical margins. A systematic method was developed for definition of a boost target volume prior to a formal phase-I study. / Material and methods: Reference structures were defined by two oncologists and one radiologist, target structures were submitted by eight oncologist investigators and compared using conformity indices. Resultant risk of duodenal bleed (NTCP) was modelled. / Results: For GTV, reference volume was 2.1 cm3 and investigator mean was 6.03 cm3 (95% CI 3.92–8.13 cm3), for boost volume 1.1 cm3 and 1.25 cm3 (1.02–1.48 cm3). Mean Dice conformity coefficient for GTV was 0.47 (0.38–0.56), and for boost volume was significantly higher at 0.61 (0.52–0.70, p = 0.01). Discordance index (DI) for GTV was 0.65 (0.56–0.75) and for boost volume was significantly lower at 0.39 (0.28–0.49, p = 0.001). NTCP using reference contours was 2.95%, with mean for investigator contour plans 3.93% (3.63–4.22%). Correlations were seen between NTCP and GTV volume (p = 0.02) and NTCP and DI (correlation coefficient 0.83 (0.29–0.97), p = 0.01). / Conclusions: Better conformity with reference was shown for boost volume compared with GTV. Investigator GTV volumes were larger than reference, had higher DI scores and modelled toxicity risk. A consistent method of target structure definition for margin-directed pancreatic radiotherapy is demonstrated.
| Type: | Article |
|---|---|
| Title: | Conformity analysis to demonstrate reproducibility of target volumes for Margin-Intense Stereotactic Radiotherapy for borderline-resectable pancreatic cancer |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.radonc.2016.08.001 |
| Publisher version: | https://doi.org/10.1016/j.radonc.2016.08.001 |
| Language: | English |
| Additional information: | Copyright © 2016 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Pancreatic cancer, Borderline-resectable, SBRT, Target volume definition, Radiation therapy quality assurance |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10119751 |
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