Malagnino, V;
Cerva, C;
Cingolani, A;
Ceccherini-Silberstein, F;
Vergori, A;
Cuomo, G;
Perno, CF;
... ICONA Foundation Study Group, .; + view all
(2021)
HBcAb Positivity Increases the Risk of Severe Hepatic Fibrosis Development in HIV/HCV-Positive Subjects From the ICONA Italian Cohort of HIV-Infected Patients.
Open Forum Infectious Diseases
, 8
(1)
, Article ofaa566. 10.1093/ofid/ofaa566.
Preview |
Text
Cozzi-Lepri_HBcAb Positivity Increases the Risk of Severe Hepatic Fibrosis Development in HIV:HCV-Positive Subjects From the ICONA Italian Cohort of HIV-Infected Patients_VoR.pdf - Published Version Download (232kB) | Preview |
Abstract
BACKGROUND: The aim of this study was to investigate the impact of anti-HBc (HBcAb) positivity on the progression of liver fibrosis (Fibrosis-4 score >3.25) in the Italian cohort of HIV-infected individuals naïve to antiretroviral treatment (ICONA). METHODS: All patients with FIB-4 <3.25 at baseline were evaluated prospectively: 6966 people with HIV (PWH) were screened and classified based on hepatitis B virus (HBV) and hepatitis C virus (HCV) serology. RESULTS: Patients who were HBcAb+/HCV-/HBs antigen (HBsAg)- and HCV+/HBcAb+/HBsAg- or HBsAg+/HBcAb+/HCV- had CD4+ cell counts below the nadir and significantly higher prevalence of AIDS diagnosis at baseline than the other groups (P < .0001). A Cox regression model adjusted for age, HIV transmission mode, country of birth, and alcohol consumption showed a higher relative risk (HR) of progression to FIB-4 >3.25 in HCV+/HBcAb+/HBsAg- patients (HR, 7.2; 95% CI, 3 8–13.64). CONCLUSIONS: HBcAb+ contributes to liver damage in HIV+/HCV+/HBcAb+/HBsAg- subjects. A careful monitoring for signs of previous HBV infection is needed in this kind of patients.
| Type: | Article |
|---|---|
| Title: | HBcAb Positivity Increases the Risk of Severe Hepatic Fibrosis Development in HIV/HCV-Positive Subjects From the ICONA Italian Cohort of HIV-Infected Patients |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/ofid/ofaa566 |
| Publisher version: | https://doi.org/10.1093/ofid/ofaa566 |
| Language: | English |
| Additional information: | © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | HBV, HIV/HBV coinfection, OBI, anti-HBc, liver fibrosis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10119673 |
Archive Staff Only
 |
View Item |
