Endurance of Short Pulse Width Thalamic Stimulation Efficacy in Intention Tremor

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Endurance of Short Pulse Width Thalamic Stimulation Efficacy in Intention Tremor

Wirth, T; Dayal, V; De Roquemaurel, A; Ferreira, F; Vijiaratnam, N; Akram, H; Zrinzo, L; ... Limousin, P; + view all (2021) Endurance of Short Pulse Width Thalamic Stimulation Efficacy in Intention Tremor. Stereotactic and Functional Neurosurgery , 99 (4) pp. 281-286. 10.1159/000511716. Green open access

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Abstract

The benefit of short pulse width stimulation in patients suffering from essential tremor (ET) refractory to thalamic deep brain stimulation remains controversial. Here, we add to the minimal body of evidence available by reporting the effect of this type of stimulation in 3 patients with a persistent and severe intention tremor component despite iterative DBS setting adjustments. While a reduction in pulse width to 30 μs initially showed promise in these patients by improving tremor control and mitigating cerebellar side effects arguably by widening the therapeutic window, these benefits seemed to dissipate during early follow-up. Our experience supports the need for measuring longer-term outcomes when reporting the usefulness of this mode of stimulation in ET.

Type:	Article
Title:	Endurance of Short Pulse Width Thalamic Stimulation Efficacy in Intention Tremor
Open access status:	An open access version is available from UCL Discovery
DOI:	10.1159/000511716
Publisher version:	https://doi.org/10.1159/000511716
Language:	English
Additional information:	This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords:	Essential Tremor, Ventral intermediate nucleus, Deep Brain Stimulation, Short pulse width, Ataxia
UCL classification:	UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI:	https://discovery.ucl.ac.uk/id/eprint/10119620