Russell, JP;
Lim, X;
Santambrogio, A;
Yianni, V;
Kemkem, Y;
Wang, B;
Fish, M;
... Andoniadou, CL; + view all
(2021)
Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells.
Elife
, 10
, Article e59142. 10.7554/eLife.59142.
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Abstract
In response to physiological demand, the pituitary gland generates new hormonesecreting cells from committed progenitor cells throughout life. It remains unclear to what extent pituitary stem cells (PSCs), which uniquely express SOX2, contribute to pituitary growth and renewal. Moreover, neither the signals that drive proliferation nor their sources have been elucidated. We have used genetic approaches in the mouse, showing that the WNT pathway is essential for proliferation of all lineages in the gland. We reveal that SOX2+ stem cells are a key source of WNT ligands. By blocking secretion of WNTs from SOX2+ PSCs in vivo, we demonstrate that proliferation of neighbouring committed progenitor cells declines, demonstrating that progenitor multiplication depends on the paracrine WNT secretion from SOX2+ PSCs. Our results indicate that stem cells can hold additional roles in tissue expansion and homeostasis, acting as paracrine signalling centres to coordinate the proliferation of neighbouring cells.
| Type: | Article |
|---|---|
| Title: | Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.7554/eLife.59142 |
| Publisher version: | https://doi.org/10.7554/eLife.59142 |
| Language: | English |
| Additional information: | This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | mouse, regenerative medicine, stem cells |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10118902 |
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