Tsutsumi, S;
Chadney, O;
Yiu, T-L;
Bäumler, E;
Faraggiana, L;
Beau, M;
Häusser, M;
(2020)
Purkinje Cell Activity Determines the Timing of Sensory-Evoked Motor Initiation.
Cell Reports
, 33
(12)
, Article 108537. 10.1016/j.celrep.2020.108537.
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Abstract
Cerebellar neurons can signal sensory and motor events, but their role in active sensorimotor processing remains unclear. We record and manipulate Purkinje cell activity during a task that requires mice to rapidly discriminate between multisensory and unisensory stimuli before motor initiation. Neuropixels recordings show that both sensory stimuli and motor initiation are represented by short-latency simple spikes. Optogenetic manipulation of short-latency simple spikes abolishes or delays motor initiation in a rate-dependent manner, indicating a role in motor initiation and its timing. Two-photon calcium imaging reveals task-related coherence of complex spikes organized into conserved alternating parasagittal stripes. The coherence of sensory-evoked complex spikes increases with learning and correlates with enhanced temporal precision of motor initiation. These results suggest that both simple spikes and complex spikes govern sensory-driven motor initiation: simple spikes modulate its latency, and complex spikes refine its temporal precision, providing specific cellular substrates for cerebellar sensorimotor control.
| Type: | Article |
|---|---|
| Title: | Purkinje Cell Activity Determines the Timing of Sensory-Evoked Motor Initiation |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.celrep.2020.108537 |
| Publisher version: | https://doi.org/10.1016/j.celrep.2020.108537 |
| Language: | English |
| Additional information: | Copyright © 2020 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | purkinje cells, simple spikes, complex spikestwo-photon imaging, optogenetics, neuropixels, cerebellum, multisensory, timing, motor initiation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10118139 |
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