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Reversal of Temporal Discrimination in Cervical Dystonia after Low-Frequency Sensory Stimulation

Erro, R; Antelmi, E; Bhatia, KP; Latorre, A; Tinazzi, M; Berardelli, A; Rothwell, JC; (2020) Reversal of Temporal Discrimination in Cervical Dystonia after Low-Frequency Sensory Stimulation. Movement Disorders 10.1002/mds.28369. (In press).

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Abstract

BACKGROUND: Somatosensory temporal discrimination is abnormal in dystonia and reflects reduced somatosensory inhibition. In healthy individuals, both the latter are enhanced by high‐frequency repetitive somatosensory stimulation, whereas opposite effects are observed in patients with cervical dystonia. OBJECTIVES: We tested whether low‐frequency repetitive sensory stimulation, which in healthy individuals worsens discrimination, might have the opposite effect in patients with cervical dystonia at the physiological level and, in turn, improve their perceptual performance. METHODS: Somatosensory temporal discrimination and several electrophysiological measures of sensorimotor inhibition were collected before and after 45 minutes of low‐frequency repetitive sensory stimulation. RESULTS: As predicted, and opposite to what happened in controls, low‐frequency repetitive sensory stimulation in patients enhanced sensorimotor inhibition and normalized somatosensory temporal discrimination. CONCLUSIONS: Patients with cervical dystonia have an abnormal response to repetitive sensory stimulation, which we hypothesize is attributed to abnormally sensitive homeostatic mechanisms of inhibitory circuitry in both sensory and motor systems.

Type: Article
Title: Reversal of Temporal Discrimination in Cervical Dystonia after Low-Frequency Sensory Stimulation
DOI: 10.1002/mds.28369
Publisher version: https://doi.org/10.1002/mds.28369
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: inhibition, temporal discrimination, pathophysiology, plasticity, somatosensory
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10117137
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