Rose, CF;
Amodio, P;
Bajaj, JS;
Dhiman, RK;
Montagnese, S;
Taylor-Robinson, SD;
Vilstrup, H;
(2020)
Hepatic encephalopathy: Novel insights into classification, pathophysiology and therapy.
Journal of Hepatology
, 73
(6)
pp. 1526-1547.
10.1016/j.jhep.2020.07.013.
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Abstract
Hepatic encephalopathy (HE) is a frequent and serious complication of both chronic liver disease and acute liver failure. HE manifests as a wide spectrum of neuropsychiatric abnormalities, from subclinical changes (mild cognitive impairment) to marked disorientation, confusion and coma. The clinical and economic burden of HE is considerable, and it contributes greatly to impaired quality of life, morbidity and mortality. This review will critically discuss the latest classification of HE, as well as the pathogenesis and pathophysiological pathways underlying the neurological decline in patients with end-stage liver disease. In addition, management strategies, diagnostic approaches, currently available therapeutic options and novel treatment strategies are discussed.
| Type: | Article |
|---|---|
| Title: | Hepatic encephalopathy: Novel insights into classification, pathophysiology and therapy |
| Location: | Netherlands |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jhep.2020.07.013 |
| Publisher version: | http://dx.doi.org/10.1016/j.jhep.2020.07.013 |
| Language: | English |
| Additional information: | © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-ncnd/4.0/ |
| Keywords: | Ammonia, Diagnosis, Hepatic encephalopathy, Management, Pathogenesis, Pathophysiology, Treatments |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10115703 |
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