Brain Volume and Neuropsychological Differences in Extremely Preterm Adolescents

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Brain Volume and Neuropsychological Differences in Extremely Preterm Adolescents

Irzan, H; O’Reilly, H; Ourselin, S; Marlow, N; Melbourne, A; (2020) Brain Volume and Neuropsychological Differences in Extremely Preterm Adolescents. In: Hu, Y and Licandro, R and Noble, JA and Hutter, J and Aylward, S and Melbourne, A and Abaci Turk, E and Torrents Barrena, J, (eds.) Medical Ultrasound, and Preterm, Perinatal and Paediatric Image Analysis. (pp. pp. 315-323). Springer: Lima, Peru. Green open access

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Abstract

Although findings have revealed that preterm subjects are at higher risk of brain abnormalities and adverse cognitive outcome, very few studies have investigated the long-term effects of extreme prematurity on regional brain structures, especially in adolescence. The current study aims to investigate the volume of brain structures of 88 extremely preterm born 19-year old adolescents and 54 age- and socioeconomically-matched full-term born subjects. In addition, we examine the hypothesis that the volume of grey matter regions where a significant group or group-sex differences are found would be connected with the neurodevelopmental outcome. The results of the analysis show regional brain difference linked to extreme prematurity with reduced grey matter content in the subcortical regions and larger grey matter volumes distributed around the medial prefrontal cortex and anterior medial cortex. Premature birth and the volume of the left precuneus and the right posterior cingulate gyrus accounts for 34% of the variance in FSIQ. The outcome of this analysis reveals that structural brain differences persist into adolescence in extremely preterm subjects and that they correlate with cognitive functions.

Type:	Proceedings paper
Title:	Brain Volume and Neuropsychological Differences in Extremely Preterm Adolescents
Event:	ASMUS 2020, PIPPI 2020: Medical Ultrasound, and Preterm, Perinatal and Paediatric Image Analysis
ISBN-13:	9783030603335
Open access status:	An open access version is available from UCL Discovery
DOI:	10.1007/978-3-030-60334-2_31
Publisher version:	https://doi.org/10.1007/978-3-030-60334-2_31
Language:	English
Additional information:	This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords:	Prematurity · Brain volume · T1-weighted MRI · Grey matter
UCL classification:	UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Neonatology UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI:	https://discovery.ucl.ac.uk/id/eprint/10115079