Patel, S;
Malmberg, K-J;
(2020)
Preventing a shock to the system. Two-pore channel 1 negatively regulates anaphylaxis.
Cell Calcium
, 92
, Article 102289. 10.1016/j.ceca.2020.102289.
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Abstract
The mammalian two-pore channels TPC1 and TPC2 are patho-physiologically relevant endo-lysosomal cation channels regulated by the Ca2+ mobilising messenger NAADP and the phosphoinositide PI(3,5)P2. Recent work by Arlt et al shows that genetic or chemical inhibition of TPC1 in mice promotes anaphylaxis in vivo through a mechanism involving enhanced endoplasmic reticulum Ca2+ release and secretion in mast cells.
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