Cui, H;
Glidle, A;
Cooper, JM;
(2020)
Highly Efficient Spatially Offset Raman Spectroscopy to Profile Molecular Composition in Bone.
IEEE Access
, 8
pp. 62905-62911.
10.1109/ACCESS.2020.2984170.
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Abstract
Spatially offset Raman spectroscopy (SORS) offers the prospect of collecting spectral information detailing the molecular composition of biomaterials at greater depths below the surface layers than are normally probed by conventional Raman spectroscopy. By collecting off-axial scattered light, the technique overcomes the large background from in-line light within scattering media. In this paper we present a configuration which enables the highly efficient collection of spectral markers, indicative of bone health, including Raman signatures to assess phosphate, collagen and carbonate content, at millimeter depths. We demonstrate the effectiveness of the technique by performing spectral decompositions to analyze the molecular distribution of these markers non-invasively, using in vitro model systems, comprising bone and tissue, in situ.
| Type: | Article |
|---|---|
| Title: | Highly Efficient Spatially Offset Raman Spectroscopy to Profile Molecular Composition in Bone |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1109/ACCESS.2020.2984170 |
| Publisher version: | http://dx.doi.org/10.1109/ACCESS.2020.2984170 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 License. For more information, see https://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Depth profile, high efficiency, spatially offset Raman spectroscopy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10114507 |
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