Howard, JL;
Schotten, C;
Browne, DL;
(2017)
Continuous flow synthesis of antimalarials: opportunities for distributed autonomous chemical manufacturing.
Reaction Chemistry & Engineering
, 2
(3)
pp. 281-287.
10.1039/c7re00034k.
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Abstract
The concept of distributed manufacturing of chemicals is presented and discussed, with specific focus on the context of preparing molecules that can combat the development of geographically-localised resistant strains of infectious pathogens. Specifically we present the case of antimalarial compounds and demonstrate that the flow chemistry community have already designed both a machine capable of distrubuted chemical manufacturing and a module that would be capable of producing artemisin derivatives at the point of use.
| Type: | Article |
|---|---|
| Title: | Continuous flow synthesis of antimalarials: opportunities for distributed autonomous chemical manufacturing |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/c7re00034k |
| Publisher version: | http://dx.doi.org/10.1039/c7re00034k |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | DRUG DISCOVERY, MALARIA, ARTEMISININ, PHOTOCHEMISTRY, STRATEGIES, MEDICINES, DEMAND |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10114376 |
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