Kutscher, D;
Asogan, D;
Mudway, I;
Brekke, P;
Beales, C;
Wang, X;
Perkins, MW;
... Stewart, TJ; + view all
(2020)
Imaging of Trace Elements Using Laser Ablation–Inductively Coupled Plasma–Mass Spectrometry: Emerging New Applications.
Spectroscopy
, 35
(S4)
pp. 16-26.
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Abstract
The qualitative and quantitative determination of trace elements is a stronghold of inductively coupled plasma–mass spectrometry (ICP-MS). Whereas in most cases the concentrations of a series of elements are determined in the bulk sample (often requiring a digestion upfront), the use of laser ablation (LA) in combination with ICP-MS allows further insight into an isotope of a given element within a sample, with the added benefit of avoiding labor intensive and contamination-prone digestion processes. LA-ICP-MS also allows the analysis of small samples with highly localized differences in trace elemental concentrations. Higher sensitivity and better interference removal using triple quadrupole instrumentation, as well as faster laser systems with specialized ablation cells enabling fast washout of material from individual laser pulses, has paved the way for new applications for LA-ICP-MS. The software supported recombination of data generated in a series of line scans covering the entire area of a sample. This was in conjunction with information on the laser position over time (using ablation rate, spot size, and stage movement velocity), allowing for the creation of a full image of elemental distributions in a sample. This is especially useful for biological samples, where the role of trace elements involved in biological processes is often unknown. This article will outline the principle of LA-ICP-MS for imaging applications, highlighting its potential to gain additional insights into the field of bioanalysis and metallomics. More specifically, the technique will be used to track the effect of environmental pollution on the distribution of heavy metals in the brain of a sentinel species in a highly urban area.
| Type: | Article |
|---|---|
| Title: | Imaging of Trace Elements Using Laser Ablation–Inductively Coupled Plasma–Mass Spectrometry: Emerging New Applications |
| Open access status: | An open access version is available from UCL Discovery |
| Publisher version: | https://www.spectroscopyonline.com/view/imaging-of... |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10113330 |
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