Carucci, S;
Balia, C;
Gagliano, A;
Lampis, A;
Buitelaar, JK;
Danckaerts, M;
Dittmann, RW;
... ADDUCE Consortium; + view all
(2021)
Long term methylphenidate exposure and growth in children and adolescents with ADHD. A systematic review and meta-analysis.
Neuroscience and Biobehavioral Reviews
, 120
pp. 509-525.
10.1016/j.neubiorev.2020.09.031.
Preview |
Text
1-s2.0-S0149763420305923-main.pdf - Accepted Version Download (5MB) | Preview |
Abstract
Background: Methylphenidate (MPH) is an efficacious treatment for ADHD but concerns have been raised about potential adverse effects of extended treatment on growth. / Objectives: To systematically review the literature, up to December 2018, conducting a meta-analysis of association of long-term (> six months) MPH exposure with height, weight and timing of puberty. / Results: Eighteen studies (ADHD n = 4868) were included in the meta-analysis. MPH was associated with consistent statistically significant pre-post difference for both height (SMD = 0.27, 95% CI 0.16-0.38, p < 0.0001) and weight (SMD = 0.33, 95% CI 0.22-0.44, p < 0.0001) Z scores, with prominent impact on weight during the first 12 months and on height within the first 24-30 months. No significant effects of dose, formulation, age and drug-naïve condition as clinical moderators were found. Data on timing of puberty are currently limited. / Conclusions: Long-term treatment with MPH can result in reduction in height and weight. However, effect sizes are small with possible minimal clinical impact. Long-term prospective studies may help to clarify the underlying biological drivers and specific mediators and moderators.
| Type: | Article |
|---|---|
| Title: | Long term methylphenidate exposure and growth in children and adolescents with ADHD. A systematic review and meta-analysis |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neubiorev.2020.09.031 |
| Publisher version: | https://doi.org/10.1016/j.neubiorev.2020.09.031 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Attention deficit/hyperactivity disorder (ADHD); methylphenidate; stimulants; height; weight; growth; puberty. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Practice and Policy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10113042 |
Archive Staff Only
 |
View Item |
