Dedrick, RM;
Guerrero-Bustamante, CA;
Garlena, RA;
Russell, DA;
Ford, K;
Harris, K;
Gilmour, KC;
... Spencer, H; + view all
(2019)
Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus.
Nature Medicine
, 25
pp. 730-733.
10.1038/s41591-019-0437-z.
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Abstract
A 15-year-old patient with cystic fibrosis with a disseminated Mycobacterium abscessus infection was treated with a three-phage cocktail following bilateral lung transplantation. Effective lytic phage derivatives that efficiently kill the infectious M. abscessus strain were developed by genome engineering and forward genetics. Intravenous phage treatment was well tolerated and associated with objective clinical improvement, including sternal wound closure, improved liver function, and substantial resolution of infected skin nodules.
| Type: | Article |
|---|---|
| Title: | Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41591-019-0437-z |
| Publisher version: | https://doi.org/10.1038/s41591-019-0437-z |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Adolescent, Cystic Fibrosis, Drug Resistance, Bacterial, Female, Genetic Engineering, Humans, Mycobacterium Infections, Nontuberculous, Mycobacterium abscessus, Phage Therapy |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10112419 |
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