Woudenbergh, EV;
Irvine, EB;
Davies, L;
Kock, MD;
Hanekom, WA;
Day, CL;
Fortune, S;
(2020)
HIV Is Associated with Modified Humoral Immune Responses in the Setting of HIV/TB Coinfection.
mSphere
, 5
(3)
10.1128/mSphere.00104-20.
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Abstract
Tuberculosis (TB) represents the largest cause of death in human immunodeficiency virus (HIV)-infected individuals in part due to HIV-related CD4+ T cell loss, rendering patients immunocompromised and susceptible to a loss of Mycobacterium tuberculosis control. However, in light of increasing data pointing to a role for humoral immunity in controlling M. tuberculosis infection, here, we aimed to define whether HIV infection also alters the humoral immune response in subjects with active and latent TB. We show that in the setting of active TB, HIV-positive individuals have significantly lower IgG responses to LAM and Ag85 than HIV-negative individuals. Furthermore, significant isotype/subclass-specific differences were frequently observed, with active TB, HIV-positive individuals demonstrating compromised antigen-specific IgM titers. HIV-infected individuals with active TB also exhibited a significant loss of influenza hemagglutinin- and tetanus toxoid-specific antibody titers at the isotype/subclass level, a symptom of broad humoral immune dysfunction likely precipitated by HIV infection. Finally, we illustrated that despite the influence of HIV infection, differences in M. tuberculosis-specific antibody profiles persist between latent and active TB disease. Taken together, these findings reveal significant HIV-associated disruptions of the humoral immune response in HIV/TB-coinfected individuals.
| Type: | Article |
|---|---|
| Title: | HIV Is Associated with Modified Humoral Immune Responses in the Setting of HIV/TB Coinfection |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1128/mSphere.00104-20 |
| Publisher version: | https://doi.org/10.1128/mSphere.00104-20 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Microbiology, HIV, antibodies, coinfection, humoral immunity, tuberculosis, HEMOLYSIN-FORMING CELLS, FC-GAMMA RECEPTORS, MYCOBACTERIUM-TUBERCULOSIS, ANTIBODY-RESPONSES, B-CELLS, ANTIRETROVIRAL THERAPY, HIGH-THROUGHPUT, T-CELLS, INFECTION, ANTIGEN |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10112190 |
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