Antonoglou, O;
Giannousi, K;
Mourdikoudis, S;
Dendrinou-Samara, C;
(2020)
Magnetic nanoemulsions as candidates for Alzheimer's disease dual imaging theranostics.
Nanotechnology
, 31
(46)
, Article 465702. 10.1088/1361-6528/abac35.
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Abstract
Alzheimer's disease (AD) is the most prevalent cause of dementia linked to the accumulation of amyloid-beta (Aβ) plaques-fibrils that impair cognitive functions. Magnetic nanoparticles (MNPs) are emerging as promising tools for the crusade against AD owning to appropriate biocompatibility and facile functionalization that can lead to theranostic agents. Herein, the fabrication of a multimodal (magnetic resonance imaging (MRI), fluorescence imaging, and drug carrier) magnetic nanoemulsion (MNE) is reported as an AD theranostic candidate. Initially zinc ferrite MNPs of high saturation magnetization (129 emu g−1) were synthesized through a modified microwave-assisted polyol process. Memantine (a registered AD drug) was labeled with fluorescein (Mem-Flu) and encapsulated with the MNPs in sodium dodecyl sulfate micelles to form the MNE. Small hydrodynamic size (107), high encapsulation (77.5%) and loading efficiencies (86.1%) and sufficient transverse relaxivity (48.7 mM−1 s−1) were achieved through the design while sustained release of Mem-Flu was unveiled by in zero-order, first-order, Higuchi and Korsmeyer–Peppas pharmacokinetic models. Moreover, the MNE acquired fluorescence imaging ability of Aβ1–42 peptide monomers and/or plaques-fibrils via the fluorescein labeling of Memantine. A novel inorganic-organic hybrid multimodal AD theranostic candidate is presented.
Type: | Article |
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Title: | Magnetic nanoemulsions as candidates for Alzheimer's disease dual imaging theranostics |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1088/1361-6528/abac35 |
Publisher version: | https://doi.org/10.1088/1361-6528/abac35 |
Language: | English |
Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
Keywords: | Science & Technology, Technology, Physical Sciences, Nanoscience & Nanotechnology, Materials Science, Multidisciplinary, Physics, Applied, Science & Technology - Other Topics, Materials Science, Physics, sodium dodecyl sulfate, magnetic nanoparticles, zinc ferrite, Memantine, amyloid-beta, polyol process, BLOOD-BRAIN-BARRIER, COLLOIDAL SUPERPARTICLES, POLYOL SYNTHESIS, NANOPARTICLES, DRUG, OLEYLAMINE, DELIVERY, WATER, NMR, RELAXATION |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Physics and Astronomy |
URI: | https://discovery.ucl.ac.uk/id/eprint/10112059 |
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