Papadopoulou, M;
Dimova, T;
Shey, M;
Briel, L;
Veldtsman, H;
Khomba, N;
Africa, H;
... Vermijlen, D; + view all
(2020)
Fetal public Vγ9Vδ2 T cells expand and gain potent cytotoxic functions early after birth.
Proceedings of the National Academy of Sciences of the United States of America
, 117
(31)
pp. 18638-18648.
10.1073/pnas.1922595117.
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Abstract
Vγ9Vδ2 T cells are a major human blood γδ T cell population that respond in a T cell receptor (TCR)-dependent manner to phosphoantigens which are generated by a variety of microorganisms. It is not clear how Vγ9Vδ2 T cells react toward the sudden microbial exposure early after birth. We found that human Vγ9Vδ2 T cells with a public/shared fetal-derived TCR repertoire expanded within 10 wk postpartum. Such an expansion was not observed in non-Vγ9Vδ2 γδ T cells, which possessed a private TCR repertoire. Furthermore, only the Vγ9Vδ2 T cells differentiated into potent cytotoxic effector cells by 10 wk of age, despite their fetal origin. Both the expansion of public fetal Vγ9Vδ2 T cells and their functional differentiation were not affected by newborn vaccination with the phosphoantigen-containing bacillus Calmette-Guérin (BCG) vaccine. These findings suggest a strong and early priming of the public fetal-derived Vγ9Vδ2 T cells promptly after birth, likely upon environmental phosphoantigen exposure.
| Type: | Article |
|---|---|
| Title: | Fetal public Vγ9Vδ2 T cells expand and gain potent cytotoxic functions early after birth |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1073/pnas.1922595117 |
| Publisher version: | https://doi.org/10.1073/pnas.1922595117 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | gammadelta, newborn, Vγ9Vδ2, infant, TCR repertoire |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10111931 |
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