Jones, AC;
Nicholson, WI;
Smallman, HR;
Browne, DL;
(2020)
A Robust Pd-Catalyzed C-S Cross-Coupling Process Enabled by Ball-Milling.
Organic Letters
, 22
(19)
pp. 7433-7438.
10.1021/acs.orglett.0c02418.
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Abstract
An operationally simple mechanochemical C–S coupling of aryl halides with thiols has been developed. The reaction process operates under benchtop conditions without the requirement for a (dry) solvent, an inert atmosphere, or catalyst preactivation. The reaction is finished within 3 h. The reaction is demonstrated across a broad range of substrates; the inclusion of zinc metal has been found to be critical in some instances, especially for coupling of alkyl thiols.
| Type: | Article |
|---|---|
| Title: | A Robust Pd-Catalyzed C-S Cross-Coupling Process Enabled by Ball-Milling |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/acs.orglett.0c02418 |
| Publisher version: | https://doi.org/10.1021/acs.orglett.0c02418 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10111920 |
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