Geng, Y;
Zhou, F;
Williams, GR;
(2021)
Developing and scaling up fast-dissolving electrospun formulations based on poly(vinylpyrrolidone) and ketoprofen.
Journal of Drug Delivery Science and Technology
, 61
, Article 102138. 10.1016/j.jddst.2020.102138.
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Abstract
Poly(vinyl pyrrolidone) (PVP) electrospun fibers loaded with ketoprofen were fabricated in this work as potential fast dissolving drug delivery systems (DDSs) for oral delivery. By changing the processing parameters and collector geometry it was possible to increase the throughput rate from 1 to 20 mL/h. The fibers all took the shape of cylinders and had smooth surfaces. They comprise amorphous solid dispersions of drug-in-polymer, with very high drug encapsulation efficiencies (100%). With a low drug loading (9.09% w/w) the electrospun materials could disintegrate quickly and accelerate the dissolution profile of ketoprofen under non-sink conditions representative of the oral cavity. However, at higher loadings (23.08% w/w), this benefit is no longer realized, indicating that there is a maximum drug loading above which the dissolution-enhancing properties of the amorphous form and the hydrophilic PVP carrier cease to be effective. After storage under ambient conditions (19–21 °C, relative humidity 30–40%) for 4 weeks, the formulations remained amorphous, with no significant changes in their drug release properties. Very similar behaviour in terms of drug release and storage stability was seen regardless of the throughput rate used for fiber fabrication, showing the potential to rapidly produce large amounts of high-performing material.
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