White, LJ;
Sutton, G;
Shechonge, A;
Day, JJ;
Dasmahapatra, KK;
Pownall, ME;
(2020)
Adaptation of the carbamoyl-phosphate synthetase (CPS) enzyme in an extremophile fish.
Royal Society Open Science
, 7
(10)
, Article 201200. 10.1098/rsos.201200.
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Abstract
Tetrapods and fish have adapted distinct carbamoyl-phosphate synthase (CPS) enzymes to initiate the ornithine urea cycle during the detoxification of nitrogenous wastes. We report evidence that in the ureotelic subgenus of extremophile fish Oreochromis Alcolapia, CPS III has undergone convergent evolution and adapted its substrate affinity to ammonia which is typical of terrestrial vertebrate CPS I. Unusually, unlike in other vertebrates, the expression of CPS III in Alcolapia is localised to the skeletal muscle and is activated in the myogenic lineage during early embryonic development with expression remaining in mature fish. We propose that adaptation in Alcolapia included both convergent evolution of CPS function to that of terrestrial vertebrates, as well as changes in development mechanisms redirecting CPS III gene expression to the skeletal muscle.
| Type: | Article |
|---|---|
| Title: | Adaptation of the carbamoyl-phosphate synthetase (CPS) enzyme in an extremophile fish |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1098/rsos.201200 |
| Publisher version: | https://doi.org/10.1098/rsos.201200 |
| Language: | English |
| Additional information: | © 2020 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10111458 |
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