Pasciuto, E;
Burton, OT;
Roca, CP;
Lagou, V;
Rajan, WD;
Theys, T;
Mancuso, R;
... Liston, A; + view all
(2020)
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.
Cell
, 182
(3)
625-+.
10.1016/j.cell.2020.06.026.
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Abstract
The brain is a site of relative immune privilege. Although CD4 T cells have been reported in the central nervous system, their presence in the healthy brain remains controversial, and their function remains largely unknown. We used a combination of imaging, single cell, and surgical approaches to identify a CD69+ CD4 T cell population in both the mouse and human brain, distinct from circulating CD4 T cells. The brain-resident population was derived through in situ differentiation from activated circulatory cells and was shaped by self-antigen and the peripheral microbiome. Single-cell sequencing revealed that in the absence of murine CD4 T cells, resident microglia remained suspended between the fetal and adult states. This maturation defect resulted in excess immature neuronal synapses and behavioral abnormalities. These results illuminate a role for CD4 T cells in brain development and a potential interconnected dynamic between the evolution of the immunological and neurological systems.
| Type: | Article |
|---|---|
| Title: | Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.cell.2020.06.026 |
| Language: | English |
| Additional information: | © 2020 The Author(s). Published by Elsevier Inc.625This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | CENTRAL-NERVOUS-SYSTEM, IMMUNE CELLS, MOUSE MODEL, BRAIN, MICE, MEMORY, ABNORMALITIES, LYMPHOCYTES, MICROBIOTA, DEFICITS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UK Dementia Research Institute HQ |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10110408 |
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