Hollis, B;
Day, FR;
Busch, AS;
Thompson, DJ;
Soares, ALG;
Timmers, PRHJ;
Kwong, A;
... Perry, JRB; + view all
(2020)
Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan.
Nature Communications
, 11
(1)
, Article 1536. 10.1038/s41467-020-14451-5.
Preview |
Text
Pashayan_Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan_VoR.pdf - Published Version Download (997kB) | Preview |
Abstract
The timing of puberty is highly variable and is associated with long-term health outcomes. To date, understanding of the genetic control of puberty timing is based largely on studies in women. Here, we report a multi-trait genome-wide association study for male puberty timing with an effective sample size of 205,354 men. We find moderately strong genomic correlation in puberty timing between sexes (rg = 0.68) and identify 76 independent signals for male puberty timing. Implicated mechanisms include an unexpected link between puberty timing and natural hair colour, possibly reflecting common effects of pituitary hormones on puberty and pigmentation. Earlier male puberty timing is genetically correlated with several adverse health outcomes and Mendelian randomization analyses show a genetic association between male puberty timing and shorter lifespan. These findings highlight the relationships between puberty timing and health outcomes, and demonstrate the value of genetic studies of puberty timing in both sexes.
| Type: | Article |
|---|---|
| Title: | Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41467-020-14451-5 |
| Publisher version: | https://doi.org/10.1038/s41467-020-14451-5 |
| Language: | English |
| Additional information: | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| Keywords: | Endocrinology, Genetics research, Genome-wide association studies, Reproductive biology |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Applied Health Research |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10110074 |
Archive Staff Only
 |
View Item |
