Huang, B-H;
Inan-Eroglu, E;
Hamer, M;
Stamatakis, E;
(2020)
Joint associations of device-measured physical activity and sleep duration with cardiometabolic health in the 1970 British Cohort Study.
Journal of Science and Medicine in Sport
, 23
(12)
pp. 1191-1196.
10.1016/j.jsams.2020.07.012.
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Abstract
OBJECTIVES: Multiple unhealthy lifestyle behaviors could synergistically exaggerate unfavorable health outcomes. The present study aimed to investigate the joint associations of device-measured sleep duration and physical activity with cardiometabolic health markers. DESIGN: A cross-sectional analysis embedded in the 46-48 years wave of the 1970 British Cohort Study. METHODS: 4756 participants wore an activPAL3 micro accelerometer to measure physical activity and sleep duration. Outcomes included body mass index (BMI), glycated hemoglobin, triglycerides, c-reactive protein, systolic blood pressure, and total-to-high-density lipoprotein (HDL) cholesterol ratio, hypertension, and diabetes. We examined the joint associations of sleep (<7h, short; 7-9h, medium; >9h, long) and physical activity (median cut of step counts, 9480 steps/d; or moderate-to-vigorous physical activity, MVPA, 085h/d) with outcomes by generalized linear models or logistic regression. RESULTS: Low physical activity combined with either short or long sleep was associated with higher BMI (e.g., 2.32 [1.42, 3.23] (kg/m2) for short sleep) compared to the referent medium sleep and high physical activity combination. Low physical activity combined with long sleep was associated with a higher total-to-HDL cholesterol ratio (e.g., 0.31 [0.12, 0.49] for low step counts). Short sleep combined with low step counts showed higher odds for hypertension and diabetes (1.34 [1.06, 1.69] and 1.98 [1.07, 3.68], respectively), while short sleep combined with either low or high MVPA had higher odds for diabetes (2.04 [1.09, 3.82] and 2.07 [1.04, 4.15], respectively). CONCLUSIONS: Low physical activity may exaggerate the detrimental associations between inadequate sleep with BMI, blood lipids, hypertension, and diabetes.
| Type: | Article |
|---|---|
| Title: | Joint associations of device-measured physical activity and sleep duration with cardiometabolic health in the 1970 British Cohort Study |
| Location: | Australia |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jsams.2020.07.012 |
| Publisher version: | http://dx.doi.org/10.1016/j.jsams.2020.07.012 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Diabetes mellitus, Exercise, Hypertension, Sleep |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10109678 |
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