Nemes, E;
Khader, SA;
Swanson, RV;
Hanekom, WA;
(2020)
Targeting Unconventional Host Components for Vaccination-Induced Protection Against TB.
Frontiers in Immunology
, 11
, Article 1452. 10.3389/fimmu.2020.01452.
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Abstract
The current tuberculosis (TB) vaccine, Bacille Calmette-Guerin (BCG), is effective in preventing TB in young children but was developed without a basic understanding of human immunology. Most modern TB vaccine candidates have targeted CD4+ T cell responses, thought to be important for protection against TB disease, but not known to be sufficient or critical for protection. Advances in knowledge of host responses to TB afford opportunities for developing TB vaccines that target immune components not conventionally considered. Here, we describe the potential of targeting NK cells, innate immune training, B cells and antibodies, and Th17 cells in novel TB vaccine development. We also discuss attempts to target vaccine immunity specifically to the lung, the primary disease site in humans.
| Type: | Article |
|---|---|
| Title: | Targeting Unconventional Host Components for Vaccination-Induced Protection Against TB |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fimmu.2020.01452 |
| Publisher version: | https://doi.org/10.3389/fimmu.2020.01452 |
| Language: | English |
| Additional information: | Copyright © 2020 Nemes, Khader, Swanson and Hanekom. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | tuberculosis, NK cells, trained immunity, B cells, Th17 Cells |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10109037 |
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