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The Jekyll and Hyde of TREM2

Rueda-Carrasco, J; Hong, S; (2020) The Jekyll and Hyde of TREM2. Trends Neurosciences , 43 (10) pp. 739-740. 10.1016/j.tins.2020.08.002. Green open access

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Abstract

In a recent paper, Gratuze et al. demonstrated a putative neuroprotective role of a key Alzheimer risk variant, TREM2R47H, against tau-mediated neurodegeneration in a mouse model of tauopathy. This study highlights the context-dependent response of microglia, and proposes antagonistic roles of TREM2 in Aβ- versus tau-mediated pathology.

Type: Article
Title: The Jekyll and Hyde of TREM2
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tins.2020.08.002
Publisher version: https://doi.org/10.1016/j.tins.2020.08.002
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Alzheimer’s disease, TREM2, microglia, tauopathy
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > UK Dementia Research Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10109001
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