Cackett, G;
Sýkora, M;
Werner, F;
(2020)
Transcriptome view of a killer: African swine fever virus.
Biochemical Society Transactions
10.1042/BST20191108.
(In press).
Preview |
Text
Werner_Transcriptome view of a killer- African swine fever virus_AOP.pdf - Published Version Download (1MB) | Preview |
Abstract
African swine fever virus (ASFV) represents a severe threat to global agriculture with the world's domestic pig population reduced by a quarter following recent outbreaks in Europe and Asia. Like other nucleocytoplasmic large DNA viruses, ASFV encodes a transcription apparatus including a eukaryote-like RNA polymerase along with a combination of virus-specific, and host-related transcription factors homologous to the TATA-binding protein (TBP) and TFIIB. Despite its high impact, the molecular basis and temporal regulation of ASFV transcription is not well understood. Our lab recently applied deep sequencing approaches to characterise the viral transcriptome and gene expression during early and late ASFV infection. We have characterised the viral promoter elements and termination signatures, by mapping the RNA-5' and RNA-3' termini at single nucleotide resolution. In this review, we discuss the emerging field of ASFV transcripts, transcription, and transcriptomics.
| Type: | Article |
|---|---|
| Title: | Transcriptome view of a killer: African swine fever virus |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1042/BST20191108 |
| Publisher version: | http://dx.doi.org/10.1042/BST20191108 |
| Language: | English |
| Additional information: | © 2020 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) |
| Keywords: | African swine fever virus, RNA polymerase, RNA sequencing, gene expression and regulation, transcription, virology |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10107489 |
Archive Staff Only
 |
View Item |
