Goh, WJ;
Lee, CK;
Zou, S;
Woon, ECY;
Czarny, B;
Pastorin, G;
(2017)
Doxorubicin-loaded cell-derived nanovesicles: an alternative targeted approach for anti-tumor therapy.
International Journal of Nanomedicine
, 12
pp. 2759-2767.
10.2147/IJN.S131786.
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Abstract
Cell-derived nanovesicles (CDNs) are an emerging class of biological drug delivery systems (DDS) that retain the characteristics of the cells they were derived from, without the need for further surface functionalization. CDNs are also biocompatible, being derived from natural sources and also take advantage of the enhanced permeability and retention effect due to their nanodimensions. Furthermore, CDNs derived from monocytes were shown to have an in vivo targeting effect, accumulating at the tumor site in a previous study conducted in a mouse tumor model. Here, we report a systematic approach pertaining to various loading methods of the chemotherapeutic drug doxorubicin into our CDNs and examine the differential cellular uptake of drug-loaded CDNs in cancerous (HeLa) and healthy (HEK293) cell lines. Lastly, we proved that the addition of doxorubicin-loaded CDNs to the HeLa and HEK293 co-cultures showed a clear discrimination toward cancer cells at the cellular level. Our results further reinforce the intriguing potential of CDNs as an alternative targeted strategy for anticancer therapy.
| Type: | Article |
|---|---|
| Title: | Doxorubicin-loaded cell-derived nanovesicles: an alternative targeted approach for anti-tumor therapy |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.2147/IJN.S131786 |
| Publisher version: | https://doi.org/10.2147/IJN.S131786 |
| Language: | English |
| Additional information: | © 2020. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License (https://creativecommons.org/licenses/by-nc/3.0/). |
| Keywords: | cell-derived nanovesicles, cell targeting, doxorubicin, antitumor therapy, extracellular vesicles, biomimetic, bionanotechnology, antitumor strategies |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10106328 |
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