Morris, EC;
(2020)
Engineered T cells Flt around their targets.
Nature Immunology
, 21
pp. 831-832.
10.1038/s41590-020-0740-3.
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Abstract
Antigen escape by solid tumors has limited the efficacy of genetically modified T cells. T cells engineered to secrete the cytokine Flt3L induce the activation of endogenous T cells, enabling a broader repertoire of tumor antigens to be targeted via the expansion of intratumoral antigen presenting cells, significantly improving tumor responses.
| Type: | Article |
|---|---|
| Title: | Engineered T cells Flt around their targets |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41590-020-0740-3 |
| Publisher version: | https://doi.org/10.1038/s41590-020-0740-3 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | Cytokines, Dendritic cells, Immunotherapy, T cells, Tumour immunology |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10106267 |
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