UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Nephrogenesis in the chick embryo

Lear, Pamela Virginia; (1993) Nephrogenesis in the chick embryo. Doctoral thesis (Ph.D), UCL (University College London). Green open access

[thumbnail of Nephrogenesis_in_the_chick_emb.pdf]
Preview
Text
Nephrogenesis_in_the_chick_emb.pdf

Download (24MB) | Preview

Abstract

The chick embryo has been used to address questions concerning morphogenesis of the urinary tissues (nephrogenesis) of vertebrates. Although of considerable biological and clinical significance, the early nephrogenic tissues in particular have been under-utilised in modern developmental analyses. The overall aims of the present study have been to integrate previous nephrogenic analyses and help to provide a framework for utilising and developing techniques and concepts in future studies. The chick embryo is particularly versatile for these purposes. In amniotes, two types of nephrogenic tissue develop in succession, the nephric and metanephric. The nephric tissues are transient but essential to metanephric development. The nephric tissues also are unusual in undergoing or even completing all stages of morphogenesis (formation, epithelial differentiation, growth and degeneration) during embryonic life. I have investigated morphological aspects of induction, migration, mitosis and apoptosis, epithelialisation and possible underlying, adhesive interactions during early nephrogenesis, i.e. from initial formation of the nephric tissues until early stages of metanephric development. While induction of the later nephric and the metanephric nephrons is generally accepted, I have shown that the patterns of formation and expression of the sialylated form of the carbohydrate antigen FC10.2 in the nephric duct and its earliest nephrons are consistent with their induction. Furthermore, there are changes in the expression of S-FC10.2 associated with epithelialisation in both the nephric and metanephric tissues. Extension of the nephric, though apparently not the metanephric, duct from its area of initial formation has been the subject of a small number of recent studies and I have (re-)examined the relative importance of migration, mitosis and apoptosis in extension of the nephric and metanephric ducts. The putative roles of adhesion in these processes are discussed.

Type: Thesis (Doctoral)
Qualification: Ph.D
Title: Nephrogenesis in the chick embryo
Open access status: An open access version is available from UCL Discovery
Language: English
Additional information: Thesis digitised by ProQuest.
Keywords: Biological sciences; Nephrogenesis
URI: https://discovery.ucl.ac.uk/id/eprint/10105887
Downloads since deposit
58Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item