Clarke, BE;
Taha, DM;
Tyzack, GE;
Patani, R;
(2020)
Regionally encoded functional heterogeneity of astrocytes in health and disease: A perspective.
GLIA
10.1002/glia.23877.
(In press).
Preview |
Text
glia.23877.pdf - Published Version Download (2MB) | Preview |
Abstract
Increasing evidence has suggested that astrocytes demonstrate striking regionally allocated functional heterogeneity. Here, we discuss how this spatiotemporally encoded diversity determines the astrocytic phenotype along a finely grained spectrum from neuroprotective to deleterious states. With increasing recognition of their diverse and evolving roles in the central neuraxis, astrocytes now represent a tractable cellular target for therapies aiming to restore neural circuit integrity in a broad range of neurodegenerative disorders. Understanding the determinants of astrocyte physiology along with the true extent of heterogeneity in their regional and subregional functions will ultimately inform therapeutic strategy in neurodegenerative diseases.
| Type: | Article |
|---|---|
| Title: | Regionally encoded functional heterogeneity of astrocytes in health and disease: A perspective |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/glia.23877 |
| Publisher version: | https://doi.org/10.1002/glia.23877 |
| Language: | English |
| Additional information: | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | aging, astrocytes, functional heterogeneity, neurodegeneration, regional identity |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10105474 |
Archive Staff Only
 |
View Item |
