Kwapong, AA;
Soares, S;
Teo, SP;
Stapleton, P;
Gibbons, S;
(2020)
Myristica lowiana Phytochemicals as Inhibitor of Plasmid Conjugation in Escherichia coli.
Evidence-Based Complementary and Alternative Medicine
, 2020
, Article 1604638. 10.1155/2020/1604638.
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Abstract
Hexane extract and methanol fraction from the stem bark of Myristica lowiana specifically and significantly inhibited the conjugal transfer of the IncW plasmid R7K, a plasmid which harbors ampicillin-, streptomycin-, and spectinomycin-resistant genes. The transfer of this plasmid via the conjugative pilli of Escherichia coli was reduced by 76.5 ± 2.0% and 79.0 ± 1.2% by hexane extract and methanol fraction of M. lowiana, respectively. The hexane extract exhibited significant anti-conjugant activity at a non-cytotoxic concentration of 100 mg/L as assessed against adult human dermal fibroblast cells. The hexane extract and methanol fraction were screened using phytochemical tests, NMR spectroscopy, IR spectroscopy, and high-resolution electrospray ionization mass spectrometry (HRESIMS) and were found to contain terpenoids, sterols, and fatty acids.
| Type: | Article |
|---|---|
| Title: | Myristica lowiana Phytochemicals as Inhibitor of Plasmid Conjugation in Escherichia coli |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1155/2020/1604638 |
| Publisher version: | http://dx.doi.org/10.1155/2020/1604638 |
| Language: | English |
| Additional information: | Copyright © 2020 Awo Afi Kwapong et al. *is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10105363 |
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