Bodor, DL;
Pönisch, W;
Endres, RG;
Paluch, EK;
(2020)
Of Cell Shapes and Motion: The Physical Basis of Animal Cell Migration.
Developmental Cell
, 52
(5)
pp. 550-562.
10.1016/j.devcel.2020.02.013.
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Abstract
Motile cells have developed a variety of migration modes relying on diverse traction-force-generation mechanisms. Before the behavior of intracellular components could be easily imaged, cell movements were mostly classified by different types of cellular shape dynamics. Indeed, even though some types of cells move without any significant change in shape, most cell propulsion mechanisms rely on global or local deformations of the cell surface. In this review, focusing mostly on metazoan cells, we discuss how different types of local and global shape changes underlie distinct migration modes. We then discuss mechanical differences between force-generation mechanisms and finish by speculating on how they may have evolved.
| Type: | Article |
|---|---|
| Title: | Of Cell Shapes and Motion: The Physical Basis of Animal Cell Migration |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.devcel.2020.02.013 |
| Publisher version: | https://doi.org/10.1016/j.devcel.2020.02.013 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10103375 |
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