Satta, G;
Witney, AA;
Begum, N;
Ortiz Canseco, J;
Boa, AN;
McHugh, TD;
(2020)
Role of Whole-Genome Sequencing in Characterizing the Mechanism of Action of para-Aminosalicylic Acid and Its Resistance.
Antimicrobial Agents and Chemotherapy
, 64
(9)
, Article e00675-20. 10.1128/AAC.00675-20.
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McHugh_Satta G et al. The role of whole genome sequencing in characterizing the mechanism of action of para-aminosalicylic acid and its resistance..pdf - Accepted Version Download (447kB) | Preview |
Abstract
Para-aminosalicylic acid (PAS) remains one of the drugs of last resort for the treatment of tuberculosis, but its mechanism of action is not completely understood yet. The main aim of this project was to identify new potential mechanisms of action and resistance to PAS by performing whole genome sequencing (WGS) on PAS-resistant laboratory mutants. A new variant in the folC gene has been identified as well as some other mutations that require further studies.
| Type: | Article |
|---|---|
| Title: | Role of Whole-Genome Sequencing in Characterizing the Mechanism of Action of para-Aminosalicylic Acid and Its Resistance |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1128/AAC.00675-20 |
| Publisher version: | https://doi.org/10.1128/AAC.00675-20 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10103136 |
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