Banerjee, G;
Wilson, D;
Ambler, G;
Hostettler, IC;
Shakeshaft, C;
Cohen, H;
Yousry, T;
... CROMIS-2 collaborators; + view all
(2020)
Longer term stroke risk in intracerebral haemorrhage survivors.
Journal of Neurology, Neurosurgery and Psychiatry
10.1136/jnnp-2020-323079.
(In press).
Preview |
Text
Werring_JNNP_CROMIS-2_ICH_3yRecurrentStrokeRisk_REV_11042020_CLEAN.pdf - Accepted Version Download (393kB) | Preview |
Abstract
Objective: To evaluate the influence of intracerebral haemorrhage (ICH) location on stroke outcomes. Methods: We included patients recruited to a UK hospital-based, multicentre observational study of adults with imaging confirmed spontaneous ICH. The outcomes of interest were occurrence of a cerebral ischaemic event (either stroke or transient ischaemic attack) or a further ICH following study entry. Haematoma location was classified as lobar or non-lobar. Results: All 1094 patients recruited to the CROMIS-2 (Clinical Relevance of Microbleeds in Stroke) ICH study were included (mean age 73.3 years; 57.4% male). There were 45 recurrent ICH events (absolute event rate (AER) 1.88 per 100 patient-years); 35 in patients presenting with lobar ICH (n=447, AER 3.77 per 100 patient-years); and 9 in patients presenting with non-lobar ICH (n=580, AER 0.69 per 100 patient-years). Multivariable Cox regression found that lobar ICH was associated with ICH recurrence (HR 8.96, 95% CI 3.36 to 23.87, p<0.0001); similar results were found in multivariable completing risk analyses. There were 70 cerebral ischaemic events (AER 2.93 per 100 patient-years); 29 in patients presenting with lobar ICH (AER 3.12 per 100 patient-years); and 39 in patients with non-lobar ICH (AER 2.97 per 100 patient-years). Multivariable Cox regression found no association with ICH location (HR 1.13, 95% CI 0.66 to 1.92, p=0.659). Similar results were seen in completing risk analyses. Conclusions: In ICH survivors, lobar ICH location was associated with a higher risk of recurrent ICH events than non-lobar ICH; ICH location did not influence risk of subsequent ischaemic events. Trial registration number: NCT02513316.
Archive Staff Only
 |
View Item |
