Marchant, NL;
Lovland, LR;
Jones, R;
Pichet Binette, A;
Gonneaud, J;
Arenaza-Urquijo, EM;
Chételat, G;
... PREVENT-AD Research Group; + view all
(2020)
Repetitive negative thinking is associated with amyloid, tau, and cognitive decline.
Alzheimer’s & Dementia
10.1002/alz.12116.
(In press).
Preview |
Text
alz.12116.pdf - Published Version Download (243kB) | Preview |
Abstract
INTRODUCTION: The Cognitive Debt hypothesis proposes that repetitive negative thinking (RNT), a modifiable process common to many psychological risk factors for Alzheimer's disease (AD) may itself increase risk. We sought to empirically examine relationships between RNT and markers of AD, compared with anxiety and depression symptoms. METHODS: Two hundred and ninety-two older adults with longitudinal cognitive assessments, including 113 with amyloid-positron emission tomography (PET) and tau-PET scans, from the PREVENT-AD cohort and 68 adults with amyloid-PET scans from the IMAP+ cohort were included. All participants completed RNT, anxiety, and depression questionnaires. RESULTS: RNT was associated with decline in global cognition (P = .02); immediate (P = .03) and delayed memory (P = .04); and global amyloid (PREVENT-AD: P = .01; IMAP+: P = .03) and entorhinal tau (P = .02) deposition. Relationships remained after adjusting for potential confounders. DISCUSSION: RNT was associated with decline in cognitive domains affected early in AD and with neuroimaging AD biomarkers. Future research could investigate whether modifying RNT reduces AD risk.
| Type: | Article |
|---|---|
| Title: | Repetitive negative thinking is associated with amyloid, tau, and cognitive decline. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/alz.12116 |
| Publisher version: | https://doi.org/10.1002/alz.12116 |
| Language: | English |
| Additional information: | © 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| Keywords: | Alzheimer's disease, amyloid, cognition, depression, repetitive negative thinking, rumination, tau, worry |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10101468 |
Archive Staff Only
 |
View Item |
