Van Aller, C;
Lara, J;
Stephan, BCM;
Donini, LM;
Eleymsfield, S;
Katzmarzyk, PT;
Wells, JCK;
... Siervo, M; + view all
(2019)
Sarcopenic obesity and overall mortality: Results from the application of novel models of body composition phenotypes to the National Health and Nutrition Examination Survey 1999-2004.
Clinical Nutrition
, 38
(1)
pp. 264-270.
10.1016/j.clnu.2018.01.022.
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Abstract
Background/Objectives: There is no consensus on the definition of sarcopenic obesity (SO), resulting in inconsistent associations of SO with mortality risk. We aim to evaluate association of dual energy x-ray absorptiometry (DXA) SO models with mortality risk in a US adult population (≥50 years). Subjects/Methods: The study population consisted of 3577 participants aged 50 years and older from the 1999–2004 National Health and Nutrition and Examination Survey with mortality follow-up data through December 31, 2011. Difference in survival time in people with and without SO defined by three body composition DXA models (Model 1: body composition phenotype model; Model 2: Truncal Fat Mass (TrFM)/Appendicular Skeletal Muscle Mass (ASM) ratio model; Model 3: Fat Mass (FM)/Fat Free Mass (FFM) ratio). The differences between the models were assessed by the acceleration failure time model, and expressed as time ratios (TR). Results: Participants age 50–70 years with SO had a significantly decreased survival time, according to the body composition phenotype model (TR: 0.92; 95% CI: 0.87–0.97), and TrFM/ASM ratio model (TR: 0.88; 95% CI: 0.81–0.95). The FM/FFM ratio model did not detect significant differences in survival time. Participants with SO aged 70 years and older did not have a significantly decreased survival time, according to all three models. Conclusions: A SO phenotype increases mortality risk in people of age 50–70 years, but not in people aged 70 years and older. The application of the body composition phenotype and the TrFM/ASM ratio models may represent useful diagnostic approaches to improve the prediction of disease and mortality risk.
| Type: | Article |
|---|---|
| Title: | Sarcopenic obesity and overall mortality: Results from the application of novel models of body composition phenotypes to the National Health and Nutrition Examination Survey 1999-2004 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.clnu.2018.01.022 |
| Publisher version: | https://doi.org/10.1016/j.clnu.2018.01.022 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Sarcopenic obesity, Body composition, Mortality |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10100690 |
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