Kirkegaard-Klitbo, DM;
Fuchs, A;
Stender, S;
Sigvardsen, PE;
Kühl, JT;
Kofoed, KF;
Køber, L;
... Benfield, T; + view all
(2020)
Prevalence and Risk Factors of Moderate to Severe Hepatic Steatosis in HIV Infection: The Copenhagen Co-Morbidity Liver Study.
Journal of Infectious Diseases
, 222
(8)
pp. 1353-1362.
10.1093/infdis/jiaa246.
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Abstract
BACKGROUND: People living with HIV (PWH) may be at risk of non-alcoholic fatty liver disease (NAFLD). We compared the prevalence of moderate-to-severe hepatic steatosis (M-HS) in PWH with HIV-uninfected controls and determined risk factors for M-HS in PWH. METHODS: The Copenhagen Co-Morbidity in HIV infection Study included 453 participants and the Copenhagen General Population Study 765 participants. None had prior or current viral hepatitis or excessive alcohol intake. M-HS was assessed by unenhanced CT liver scan defined by liver attenuation ≤48 Hounsfield units. Adjusted odds ratios (aOR) were computed by adjusted logistic regression. RESULTS: The prevalence of M-HS was lower in PWH compared to uninfected controls (8.6% vs. 14.2%, p<0.01). In multivariable analyses, HIV (aOR:0.44, p<0.01); female sex (aOR:0.08, p=0.03); physical activity level (aOR 0.09 very active vs inactive, p<0.01); and alcohol (aOR:0.89 per unit/week, p=0.02) was protective factors, while BMI (aOR:1.58 per 1 kg/m2, p<0.01); ALT (aOR:1.76 per 10 U/L, p<0.01); and exposure to integrase inhibitors (aOR: 1.28 per year, p=0.02) were associated with higher odds of M-HS. CONCLUSIONS: Moderate-to-severe hepatic steatosis is less common in PWH compared to demographically comparable uninfected controls. Besides BMI and ALT, integrase inhibitor exposure was associated with higher prevalence of steatosis in PWH.
| Type: | Article |
|---|---|
| Title: | Prevalence and Risk Factors of Moderate to Severe Hepatic Steatosis in HIV Infection: The Copenhagen Co-Morbidity Liver Study |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/infdis/jiaa246 |
| Publisher version: | http://dx.doi.org/10.1093/infdis/jiaa246 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | NAFL, NAFLD, comorbidity, fatty liver disease, human immunodeficiency virus |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10099362 |
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