Emmanouilidou, E;
Papagiannakis, N;
Kouloulia, S;
Galaziou, A;
Antonellou, R;
Papadimitriou, D;
Athanasiadou, A;
... Stefanis, L; + view all
(2020)
Peripheral alpha-synuclein levels in patients with genetic and non-genetic forms of Parkinson's disease.
Parkinsonism & Related Disorders
, 73
pp. 35-40.
10.1016/j.parkreldis.2020.03.014.
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Abstract
BACKGROUND: Variations of α-synuclein levels have been reported in serum and plasma in Parkinson's Disease (PD) Patients. METHODS: Serum and plasma were obtained from PD patients without known mutations (GU-PD, n = 124)), carriers of the A53T/G209A point mutation in the α-synuclein gene (SNCA) (n = 29), and respective age-/sex-matched controls. Levels of total α-synuclein were assessed using an in-house ELISA assay. RESULTS: A statistically significant increase of α-synuclein levels was found in serum, but not plasma, from GU-PD patients compared to healthy controls. A statistically significant decrease of α-synuclein levels was found in serum and plasma from symptomatic A53T mutation carriers compared to healthy controls. Plasma α-synuclein levels were modestly negatively correlated with UPDRS part III score and disease duration in A53T-PD patients. CONCLUSION: Increased α-synuclein levels in serum of GU-PD patients suggest a systemic deregulation of α-synuclein homeostasis in PD. The opposite results in A53T-PD highlight the complexity of α-synuclein homeostatic regulation in PD, and suggest the possibility of reduced expression of the mutant allele.
| Type: | Article |
|---|---|
| Title: | Peripheral alpha-synuclein levels in patients with genetic and non-genetic forms of Parkinson's disease |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.parkreldis.2020.03.014 |
| Publisher version: | https://doi.org/10.1016/j.parkreldis.2020.03.014 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | A53T, Alpha-synuclein, Parkinson disease, Plasma, Serum |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10099182 |
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