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Peripheral alpha-synuclein levels in patients with genetic and non-genetic forms of Parkinson's disease

Emmanouilidou, E; Papagiannakis, N; Kouloulia, S; Galaziou, A; Antonellou, R; Papadimitriou, D; Athanasiadou, A; ... Stefanis, L; + view all (2020) Peripheral alpha-synuclein levels in patients with genetic and non-genetic forms of Parkinson's disease. Parkinsonism & Related Disorders , 73 pp. 35-40. 10.1016/j.parkreldis.2020.03.014. Green open access

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Abstract

BACKGROUND: Variations of α-synuclein levels have been reported in serum and plasma in Parkinson's Disease (PD) Patients. METHODS: Serum and plasma were obtained from PD patients without known mutations (GU-PD, n = 124)), carriers of the A53T/G209A point mutation in the α-synuclein gene (SNCA) (n = 29), and respective age-/sex-matched controls. Levels of total α-synuclein were assessed using an in-house ELISA assay. RESULTS: A statistically significant increase of α-synuclein levels was found in serum, but not plasma, from GU-PD patients compared to healthy controls. A statistically significant decrease of α-synuclein levels was found in serum and plasma from symptomatic A53T mutation carriers compared to healthy controls. Plasma α-synuclein levels were modestly negatively correlated with UPDRS part III score and disease duration in A53T-PD patients. CONCLUSION: Increased α-synuclein levels in serum of GU-PD patients suggest a systemic deregulation of α-synuclein homeostasis in PD. The opposite results in A53T-PD highlight the complexity of α-synuclein homeostatic regulation in PD, and suggest the possibility of reduced expression of the mutant allele.

Type: Article
Title: Peripheral alpha-synuclein levels in patients with genetic and non-genetic forms of Parkinson's disease
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.parkreldis.2020.03.014
Publisher version: https://doi.org/10.1016/j.parkreldis.2020.03.014
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: A53T, Alpha-synuclein, Parkinson disease, Plasma, Serum
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10099182
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