Kissane, RWP;
Wright, O;
Al'Joboori, YD;
Marczak, P;
Ichiyama, RM;
Egginton, S;
(2019)
Effects of treadmill training on microvascular remodeling in the rat after spinal cord injury.
Muscle & Nerve
, 59
(3)
pp. 370-379.
10.1002/mus.26379.
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Abstract
Introduction : The morphological characteristics of skeletal muscles innervated caudal to a spinal cord injury (SCI) undergo dramatic phenotypic and microvascular changes. Method : Female Sprague–Dawley rats received a severe contusion at thoracic level 9/10 and were randomly assigned to locomotor training, epidural stimulation, or a combination of the treatment groups (CB). Fiber type composition and capillary distribution were assessed in phenotypically distinct compartments of the tibialis anterior. Results : Spinal cord injury induced a shift in type II fiber phenotype from oxidative to glycolytic (P < 0.05) as well as capillary loss within the oxidative core and glycolytic cortex; the CB treatment best maintained capillary supply within both compartments. Discussion : The angiogenic response of CB training improved capillary distribution across the muscle; capillary distribution became spatially more homogeneous and mean capillary supply area decreased, potentially improving oxygenation. There is an important role for weight‐bearing training in maintaining the oxidative phenotype of muscle after SCI. Muscle Nerve 59 :370–379, 2019
| Type: | Article |
|---|---|
| Title: | Effects of treadmill training on microvascular remodeling in the rat after spinal cord injury |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/mus.26379 |
| Publisher version: | https://doi.org/10.1002/mus.26379 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences, Neurosciences & Neurology, angiogenesis, capillary domain area, epidural stimulation, skeletal muscle, spinal cord injury, treadmill training, SKELETAL-MUSCLE, CHONDROITINASE ABC, BODY-WEIGHT, FIBER TYPES, SOLEUS, STIMULATION, ADAPTATIONS, INDIVIDUALS, PERFORMANCE, MORPHOLOGY |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10098921 |
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