Oesterreich, S;
Lindemann, M;
Goldblatt, D;
Horn, PA;
Wilde, B;
Witzke, O;
(2020)
Humoral response to a 13-valent pneumococcal conjugate vaccine in kidney transplant recipients.
Vaccine
, 38
(17)
pp. 3339-3350.
10.1016/j.vaccine.2020.02.088.
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Abstract
Background: Vaccination against S. pneumoniae is recommended by national guidelines. Moderate immunogenicity of the 13-valent pneumococcal conjugate vaccine (PCV13) has been reported in adult kidney transplant recipients (KTR). This study further defines the immunogenicity of PCV13 in this cohort. Methods: 49 KTR were immunized with PCV13. A validated opsonophagocytic killing assay (OPA), a global anti-pneumococcal capsular polysaccharide (anti-PCP) IgG, IgG2, IgM and IgA ELISA, and - for selected patients - a serotype specific anti-PCP WHO reference ELISA were performed pre-vaccination and at month 1 and 12 post-vaccination. Results: Geometric mean OPA titers increased significantly for 13/13 serotypes at month 1 and for 10/13 serotypes at month 12 post-vaccination. Vaccine response defined as an OPA titer ≥1:8 was reached in 9/13 serotypes (median). 53% reached the vaccine response criteria at month 1 and 45% at month 12. At month 1 after vaccination, the median OPA titer in an age-group matched healthy reference population was 5- to 10-fold higher than in KTR. OPA titers correlated strongly with results to the global and serotype specific anti-PCP IgG ELISA. Lower OPA titers significantly (p < 0.05) correlated with albuminuria, an interval between vaccination and transplantation <12 months, age and treatment with mycophenolate mofetil. Global IgG, IgG2, IgM and IgA, as well as serotype specific anti-PCP antibody concentrations (12/13 serotypes) increased significantly at month 1 and 12 post-vaccination. Conclusions: Kidney transplant recipients show a significant humoral response after vaccination with PCV13. Functional antibody response exists, but is not as vigorous as in healthy adults.
| Type: | Article |
|---|---|
| Title: | Humoral response to a 13-valent pneumococcal conjugate vaccine in kidney transplant recipients |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.vaccine.2020.02.088 |
| Publisher version: | http://dx.doi.org/10.1016/j.vaccine.2020.02.088 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Pneumococcal conjugate vaccine, Opsonophagocytic assay, Kidney transplant recipients, Serotype specific, Pneumococcal antibody global serum assays, Pneumococcal vaccination in immunocompromised individuals, STREPTOCOCCUS-PNEUMONIAE, CAPSULAR POLYSACCHARIDES, HAEMOPHILUS-INFLUENZAE, HEALTHY-CHILDREN, DOUBLE-BLIND, ANTIBODIES, ADULTS, IMMUNOGENICITY, IMMUNITY, SEROTYPE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10097304 |
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