UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Evolution of white matter damage in amyotrophic lateral sclerosis

Gabel, MC; Broad, RJ; Young, AL; Abrahams, S; Bastin, ME; Menke, RAL; Al-Chalabi, A; ... Cercignani, M; + view all (2020) Evolution of white matter damage in amyotrophic lateral sclerosis. Annals of Clinical and Translational Neurology , 7 (5) pp. 722-732. 10.1002/acn3.51035. Green open access

[thumbnail of acn3.51035.pdf]
Preview
Text
acn3.51035.pdf - Published Version

Download (800kB) | Preview

Abstract

OBJECTIVE: To characterize disease evolution in amyotrophic lateral sclerosis using an event-based model designed to extract temporal information from cross-sectional data. Conventional methods for understanding mechanisms of rapidly progressive neurodegenerative disorders are limited by the subjectivity inherent in the selection of a limited range of measurements, and the need to acquire longitudinal data. METHODS: The event-based model characterizes a disease as a series of events, each comprising a significant change in subject state. The model was applied to data from 154 patients and 128 healthy controls selected from five independent diffusion MRI datasets acquired in four different imaging laboratories between 1999 and 2016. The biomarkers modeled were mean fractional anisotropy values of white matter tracts implicated in amyotrophic lateral sclerosis. The cerebral portion of the corticospinal tract was divided into three segments. RESULTS: Application of the model to the pooled datasets revealed that the corticospinal tracts were involved before other white matter tracts. Distal corticospinal tract segments were involved earlier than more proximal (i.e., cephalad) segments. In addition, the model revealed early ordering of fractional anisotropy change in the corpus callosum and subsequently in long association fibers. INTERPRETATION: These findings represent data-driven evidence for early involvement of the corticospinal tracts and body of the corpus callosum in keeping with conventional approaches to image analysis, while providing new evidence to inform directional degeneration of the corticospinal tracts. This data-driven model provides new insight into the dynamics of neuronal damage in amyotrophic lateral sclerosis.

Type: Article
Title: Evolution of white matter damage in amyotrophic lateral sclerosis
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/acn3.51035
Publisher version: https://doi.org/10.1002/acn3.51035
Language: English
Additional information: © 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: https://discovery.ucl.ac.uk/id/eprint/10097116
Downloads since deposit
38Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item