Sungnak, W;
Huang, N;
Bécavin, C;
Berg, M;
Queen, R;
Litvinukova, M;
Talavera-López, C;
... HCA Lung Biological Network; + view all
(2020)
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.
Nature Medicine
, 26
pp. 681-687.
10.1038/s41591-020-0868-6.
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Abstract
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells’ potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.
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