Tamosiunas, A;
Sapranaviciute-Zabazlajeva, L;
Luksiene, D;
Virviciute, D;
Bobak, M;
(2020)
Cognitive Function and Mortality: Results from Kaunas HAPIEE Study 2006-2017.
International Journal of Environmental Research and Public Health
, 17
(7)
, Article 2397. 10.3390/ijerph17072397.
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Abstract
BACKGROUND: The purpose of the study is to evaluate the association between cognitive function and risk of all-cause and cardiovascular disease mortality during 10 years of the follow-up. METHODS: 7087 participants were assessed in the baseline survey of the Health Alcohol Psychosocial Factors in Eastern Europe (HAPIEE) study in 2006-2008. During 10 years of follow-up, all-cause and CVD mortality risk were evaluated. RESULTS: During 10 years of follow-up, 768 (23%) men and 403 (11%) women died (239 and 107 from CVD). After adjustment for sociodemographic, biological, lifestyle factors, and illnesses, a decrease per 1 standard deviation in different cognitive function scores increased risk for all-cause mortality (by 13%-24% in men, and 17%-33% in women) and CVD mortality (by 19%-32% in men, and 69%-91% in women). Kaplan-Meier survival curves for all-cause and CVD mortality, according to tertiles of cognitive function, revealed that the lowest cognitive function (1st tertile) predicts shorter survival compared to second and third tertiles (p < 0.001). CONCLUSIONS: The findings of this follow-up study suggest that older participants with lower cognitive functions have an increased risk for all-cause and CVD mortality compared to older participants with a higher level of cognitive function.
| Type: | Article |
|---|---|
| Title: | Cognitive Function and Mortality: Results from Kaunas HAPIEE Study 2006-2017 |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/ijerph17072397 |
| Publisher version: | https://doi.org/10.3390/ijerph17072397 |
| Language: | English |
| Additional information: | © 2020 by the Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | all-cause mortality, cardiovascular mortality, cognitive functions |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10096330 |
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