Macerollo, A;
Zrinzo, L;
Akram, H;
Foltynie, T;
Limousin, P;
(2020)
Subthalamic nucleus deep brain stimulation for Parkinson's disease: current trends and future directions.
Expert Review of Medical Devices
, 17
(10)
pp. 1063-1074.
10.1080/17434440.2020.1747433.
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Abstract
Over the last three decades, extensive basic and clinical research has been performed on the use of subthalamic nucleus (STN) as the preferred deep brain stimulation (DBS) target for the treatment of Parkinson’s disease (PD). The mechanism underlying the benefit for the motor symptoms in PD is related to the modulation of firing patterns within the hyperdirect projections from motor cortical areas, as well as within the afferent and efferent fibers to the motor STN. Advancements in neuroimaging techniques allow us to identify precisely the STN optimizing surgical targeting. In this review, we provide an update on the current uses of STN-DBS as a routine therapy as well as its experimental indications in PD, the critical aspects associated with its successful implementation and recent advances in DBS technology.
| Type: | Article |
|---|---|
| Title: | Subthalamic nucleus deep brain stimulation for Parkinson's disease: current trends and future directions |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/17434440.2020.1747433 |
| Publisher version: | https://doi.org/10.1080/17434440.2020.1747433 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Deep brain stimulation, lead technology, neurophysiology, neuroimaging side effects, subthalamic nucleus, neuroimaging, side effects |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10095479 |
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