Strnad, P;
McElvaney, NG;
Lomas, DA;
(2020)
Alpha₁-Antitrypsin Deficiency.
The New England Journal of Medicine
, 382
(15)
pp. 1443-1455.
10.1056/NEJMra1910234.
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Abstract
AAT is a protease inhibitor targeting neutrophil elastase. It prevents the destruction of tissue, particularly in the lung, from elastase activity. AAT deficiency is a genetic disorder characterized by pulmonary disease, especially emphysema and bronchiectasis, and hepatic disease.
| Type: | Article |
|---|---|
| Title: | Alpha₁-Antitrypsin Deficiency |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1056/NEJMra1910234 |
| Publisher version: | https://doi.org/10.1056/NEJMra1910234 |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > VP: Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10095434 |
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