MacLennan, CA;
Richter, A;
Hodson, J;
Faustini, S;
Birtwistle, J;
Whitelegg, A;
Chigiga, J;
... Manavi, K; + view all
(2016)
Brief Report: Immunization of HIV-Infected Adults in the UK With Haemophilus influenzae b/Meningococcal C Glycoconjugate and Pneumococcal Polysaccharide Vaccines.
JAIDS Journal of Acquired Immune Deficiency Syndromes
, 73
(3)
pp. 287-293.
10.1097/qai.0000000000001054.
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Mainey_MacLennan+et+al,+Immunization+of+HIV-infected+adults+in+the+UK+with+Haemophilus+influenzae+b-meningococcal+C+glycoconjugat_extracted.pdf - Accepted Version Download (1MB) | Preview |
Abstract
U.K. guidelines for vaccinating HIV-infected adults against bacteria are based on limited data. We compared antibody responses between 211 HIV-infected and 73 HIV-uninfected adults vaccinated with pneumococcal polysaccharide vaccine (PPV) and Haemophilus influenzae b/meningococcal C polysaccharide-tetanus toxoid glycoconjugate vaccine (Hib/MenC-TT). IgG responses to Hib/MenC-TT were not significantly different. PPV induced median IgGs >1.3 μg/mL for 10/12 serotypes among HIV-uninfected participants and 5/12 in HIV-infected participants. HIV-uninfected adults had higher post-vaccination IgGs than HIV-infected adults for 4/12 serotypes (P < 0.001). Responses did not associate with CD4 count or viral suppression. In a U.K. HIV-infected population, Hib/MenC-TT induced similar responses to HIV-uninfected adults, whereas PPV induced poor responses.
| Type: | Article |
|---|---|
| Title: | Brief Report: Immunization of HIV-Infected Adults in the UK With Haemophilus influenzae b/Meningococcal C Glycoconjugate and Pneumococcal Polysaccharide Vaccines |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1097/qai.0000000000001054 |
| Publisher version: | https://doi.org/10.1097/qai.0000000000001054 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10094760 |
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