Szychot, E;
Seunarine, K;
Robles, C;
Mandeville, H;
Mankad, K;
Clark, C;
Peregud-Pogorzelski, J;
(2020)
Estimating brain volume loss after radiation therapy in children treated for posterior fossa tumors (Corpus callosum and whole brain volume changes following radiotherapy in children).
Advances in Clinical and Experimental Medicine
, 29
(3)
10.17219/acem/114827.
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Abstract
Background. More than half of pediatric tumors of central nervous system (CNS) primarily originate intheposterior fossa and are conventionally treated with radiation therapy (RT). Objectives. The objective of this study was to establish whether corpus callosum volumes (CCV) and whole brain volumes (WBV) are correlated and todetermine theimpact of whole-brain low- vs high-dose RT onbrain parenchymal volume loss asassessed using each technique. / Material and methods. Of the30 identified children (6–12years) with newly diagnosed posterior fossa tumors treated with cranial RT, including focal and whole-brain RT, suitable imaging was obtained for 23. Radiotherapy regimens were thefollowing: no whole-brain RT (Group1, n = 7), low-dose whole-brainRT (<30 Gy, Group2, n=9) and high-dose whole-brain RT (>30 Gy, Group3, n=7) inaddition tofocal boost. Magnetic resonance images (MRIs) were analyzed atbaseline and follow-up (median 14months). TheCCVs were manually segmented onmidline sagittal slice (n=23), while WBVs were segmented semi-automatically using Freesurfer (n = 15). This was done twice (6-month interval) for all baseline CCV measurements and 5 randomly selected WBV measurements to establish measurement reproducibility. Correlations between CCV and WBV were investigated and percentage ofchildren demonstrating reduction inCCV orWBV noted. / Results. Correlation between baseline CCV and WBV was not significant (p = 0.37). Measurement reproducibility was from 6% to –9% for CCV and from 4.8% to –1.2% for WBV. Among the children studied, 30.4% (7/23) had >9% reduction inCCV at follow-up, while 33.3% (5/15) had >1.2% reduction in WBV. Five of7patients with CCV loss were not picked up by WBV measurements. Similarly, 3 of5patients with WBV loss were not picked up byCCV measurements. / Conclusions. The CCV and the WBV are unrelated and may indicate different brain parenchymal losses following RT. Up to a third of posterior fossa tumors treated with RT have measurable CCV or WBV loss; incidence was equivalent inlow- vs high-dose whole-brain RT.
| Type: | Article |
|---|---|
| Title: | Estimating brain volume loss after radiation therapy in children treated for posterior fossa tumors (Corpus callosum and whole brain volume changes following radiotherapy in children) |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.17219/acem/114827 |
| Publisher version: | https://doi.org/10.17219/acem/114827 |
| Language: | English |
| Additional information: | Copyright © 2020 by Wroclaw Medical University. This is an article distributed under the terms of the Creative Commons Attribution 3.0 Unported (CC BY 3.0) (https://creativecommons.org/licenses/by/3.0/). |
| Keywords: | posterior fossa tumor, radiotherapy, brain volume |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10094383 |
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